• 抗原物种:
  Human
• 描述
  Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G-protein coupled adrenoceptors, A1, A2A, A2B and A3, is responsible for these effects. A3, which couples to Gi/o, is expressed in a wide range of human tissues, but most predominantly in the lung and liver. Recent animal model studies have shown that A3 receptors play important roles in brain ischemia, immunosuppresion, and bronchospasm. A3 receptor agonists and/or agonists may have important clinical value in the treatment of asthma and inflammation. Mice lacking A3 receptors display reduced mast cell degranulation and bronchoconstriction in response to adenosine.
• 图片:
  

  [1 Image]

• 抗原物种:
  Human
• 描述
  CysLT1 (Cysteinyl leukotriene receptor 1) is previous named as LTD4 receptor (leukotriene D4 receptor). It is a receptor for cysteinyl leukotrienes and has highest affinity to leukotriene D4 (LTD4). The receptor mediates contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung caused by LTD4. A CysLT1 selective antagonist, montelukast, is used clinically in the treatment of asthma.. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
• 图片:
  

  [2 Images]

3 Citations

• 应用:
  ELISA; WB; WB;
• 亚型:
  Rabbit IgG
• 偶物联:
  Unconjugated
• 免疫原:
  A synthetic CBP tag peptide KRRWKKNFIAVSAANRFKKISSSGAL conjugated to KLH
• 图片:
  

  [4 Images]

• 应用:
  ELISA; FCM; WB;
• 亚型:
  Rabbit IgG, κ
• 偶物联:
  Unconjugated
• 免疫原:
  This information is confidential and belongs to GenScript.
• 图片:
  

  [7 Images]

• 应用:
  ICC/IF;
• 亚型:
  Mouse IgG2b,κ
• 偶物联:
  iFluor 555
• 免疫原:
  A synthetic peptide DYKDDDDK coupled to KLH
• 图片:
  

  [2 Images]

• 抗原物种:
  Human
• 描述
  The bombesin receptor family is a member of the G protein-coupled receptor superfamily and consists of three subtypes of receptors: BB1 (neuromedin B receptor), BB2 (gastrin-releasing peptide receptor), and BB3. These receptors are widely distributed in mammals especially in the CNS and gastrointestinal tract and have numerous effects both physiologically and in pathologic processes including having an autocrine growth action on normal tissues and tumors; potent CNS effects (satiety, circadian rhythm, various behaviors); and potent effects in the immune, gastrointestinal, respiratory and urogenital systems. BB3 is an orphan receptor, with a high degree of homology to the BB1 and BB2 receptors, but has an unknown natural ligand because it has low affinity for all naturally occurring bombesin-related peptides. Interaction of ligand and BB3 activates the Gαq/11 pathway and increase the intracellular calcium concentration. GenScript's BB3-expressing stable cell line was made in CHO-K1 host cell and optimized for calcium assays.
• 图片:
  

  [2 Images]

• 抗原物种:
  Human
• 描述
  The bombesin receptor family is a member of the G protein-coupled receptor superfamily and consists of three subtypes of receptors: BB1 (neuromedin B receptor), BB2 (gastrin-releasing peptide receptor), and BB3. These receptors are widely distributed in mammals especially in the CNS and gastrointestinal tract and have numerous effects both physiologically and in pathologic processes including having an autocrine growth action on normal tissues and tumors; potent CNS effects (satiety, circadian rhythm, various behaviors); and potent effects in the immune, gastrointestinal, respiratory and urogenital systems. The human BB2 receptor has a greater than 50-fold higher affinity for gastrin-releasing peptide than neuromedin B. Interaction of ligand and BB2 activates the Gαq/11 pathway and increase the intracellular calcium concentration. GenScript’s BB2-expressing stable cell line was made in CHO-K1 host cell and optimized for calcium assays.
• 图片:
  

  [3 Images]

2 Citations

• 应用:
  ELISA;
• 亚型:
  Recombinant human IgM
• 偶物联:
  Unconjugated
• 免疫原:
  Recombinant SARS-CoV-2 RBD Protein
• 图片:
  

  [1 Image]

• 抗原物种:
  Human
• 描述
  The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three types: V1A (vascular/hepatic) and V1B (anterior pituitary) receptors, which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+; and V2 (kidney) receptor, which is coupled to adenylate cyclase. V1B receptors are expressed in anterior pituitary where they mediate the release of ACTH . Its peripheral actions, such as antidiuresis, contraction of vascular smooth muscle, and stimulation of hepatic glycogenolysis are well characterized.
• 图片:
  

  [2 Images]

• 抗原物种:
  Human
• 描述
  Chemokine (C-X-C motif) receptor 1 (CXCR1) is a rhodopsin-like G protein-coupled receptor. It is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses. The structure of human CXCR1 in a lipid bilayer should help to facilitate the discovery of new compounds that interact with GPCRs. GenScript’s human CXCR1-expressing stable subline is guaranteed to function properly in the calcium flux assay.
• 图片:
  

  [2 Images]