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Recombinant baculovirus-based vaccine expressing M2 protein induces protective CD8 T-cell immunity against respiratory syncytial virus infection

J Microbiol. 2017-10-01; 
Jeong-Yoon Lee, Jun Chang
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Codon Optimization … Genes and Expression Vectors Two variants of a cDNA clone corresponding to residues 26 to 515 of the F protein of an European isolate of RSV serotype A (Genbank accession number JX015498.1) [30] were synthesized using human-preferred codons by GenScript USA Inc … Get A Quote

摘要

Respiratory syncytial virus (RSV) is an important cause of acute lower respiratory tract disease in infants, young children, immunocompromised individuals, and the elderly. However, despite ongoing efforts to develop an RSV vaccine, there is still no authorized RSV vaccine for humans. Baculovirus has attracted attention as a vaccine vector because of its ability to induce a high level of humoral and cellular immunity, low cytotoxicity against various antigens, and biological safety for humans. In this study, we constructed a recombinant baculovirus- based vaccine expressing the M2 protein of RSV under the control of cytomegalovirus promoter (Bac_RSVM2) to induce CD8 T-cell responses which play an important role... More

关键词

cd8 t cells, m2 protein, recombinant baculovirus, respiratory syncytial virus, vaccine
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